Abstract: For sustained drug release, polymers are the preferred choice as they provide complex matrix which can load both hydrophobic as well as hydrophilic drug and help in improving the pharmacokinetic parameters of the drugs. In recent times, proteins based materials haveb emerged as the excipient of choice for developing formulations of neutraceutical and pharmaceutical applications. Proteins as an excipient offer several advantages like biodegradability, biocompatibility and possibility of interaction with a wide range of bioactive or pharmacologically important molecules. In the present
talk, the effects of physico-chemical properties like size and surface characteristic of protein nanoparticles on the cellular uptake of model hydrophobic drug, curcumin will be discussed.
About the Speaker: Dr. Beena G. Singh is a Scientific Officer at Bhabha Atomic Research Centre, India. Her research work is involved in developing organoselenium compounds as new class of antioxidants, which shows both free radical scavenging and enzyme mimicking activity that enables higher antioxidant/radioprotection activity even at low concentration. Her expertise on the redox chemistry of sulfur/ selenium is being utilized to prepare protein and metal nanoparticles for efficient anti- cancer drug delivery. She has published 65 papers in peer-reviewed journals. She is recipient of Scientific & Technical Excellence Award from Department of Atomic Energy, 2015.