Faculty

Dr Bhupathiraju is an Assistant Professor of Medicine and Nutrition at Harvard Medical School and Harvard T.H. Chan School of Public Health and an Associate Epidemiologist at the Brigham and Women’s Hospital. Her research focuses on dietary and lifestyle predictors of cardiometabolic diseases, especially among high-risk populations such as South Asians, Asian Indians, and Hispanics. She utilises cutting-edge omic technologies to identify dietary biomarkers and mechanisms through which diet influences disease risk.

Dr Bhupathiraju is funded by several research projects from the National Institutes of Health and USDA. Below is a list of active and completed grants

No Award #
BWH Innovation Evergreen Fund
01/2024-12/2024
Bhupathiraju, SN. (PI)
Proteomic Signatures of a Mediterranean Diet Intervention and Diabetes Risk

59-0204-3-007
USDA
09/2023-08/2026
Bhupathiraju, SN (PI)
Effect of Peanut on Glycemic Control, Cardiometabolic Risk, and General Wellness Among Overweight and Obese Asian Indians

59-0204-3-007
USDA
09/2023-08/2026
Bhupathiraju, SN (PI)
Effect of Peanut on Glycemic Control, Cardiometabolic Risk, and General Wellness Among Overweight and Obese Asian Indians

R01DK125273
NIH/NIDDK
08/2020 – 04/2024
Hirschhorn, J. (PI), Role: Co-Investigator
Metabolomics from a Controlled Feeding Study and Large Cohorts to Identify Diet-Associated Biomarkers, Augmented by Genetics to Infer Causality for Cardiometabolic Outcomes

1U2CDK129670-01
NIH/NIDDK
08/2021 – 06/2026
Clish, C. (PI), Role: Project Director
Dietary Biomarkers Development Center at Harvard University

1R01DK120560-01
NIH/NIDDK
Bhupathiraju, S. (PI)
04/10/2019-3/31/2023
Saliva and Plasma Metabolomic Signatures of Diabetes Progression in a Hispanic Cohort

R01DK112940
Hu, F. (PI) et al. Role: Co-Investigator
NIH/NIDDK
01/25/2018 – 12/31/2021
Circulating Plasma Metabolites, Diet, and Risk of Type 2 Diabetes

No Award #
Sun, Q. (PI),   Role: Co-Investigator
HSPH
01/01/2020 – 12/31/2021
Interdisciplinary Projects on Metabolic Risk Factors of Cardiovascular Disease

No Award #
Ambuja Cement Foundation
Bhupathiraju, S. PI
11/13/2019-07/31/2021
Evaluation of the ACF Non-Communicable Disease Program

K01DK107804
NIH/NIDDK
Bhupathiraju (PI)
07/2016 – 08/2020
Metabolomics and Type 2 Diabetes in a Cohort of Older Puerto Ricans

OPP1156009
Bill and Melinda Gates Foundation
Willett, W. PI,  Role: co-PI

• Bhupathiraju SN, Alekel DL, Stewart JW, Hanson LN, Shedd KM, Reddy MB, Hanson KB, Van Loan MD, Genschel U, Koehler KJ. Relationship of circulating total homocysteine and C-reactive protein to trabecular bone in postmenopausal women. J Clin Densitom. 2007;10(4):395-403. PMID: 17662632.
• Perry CD, Alekel DL, Ritland LM, Bhupathiraju SN, Stewart JW, Hanson LN, Matvienko OA, Kohut ML, Reddy MB, Van Loan MD, Genschel U. Centrally located body fat is related to inflammatory markers in healthy postmenopausal women. Menopause. 2008;15(4 Pt 1):619-27. PMID: 18202591.
• Santoro N. Targeting regional body fat: the good, the bad, and the ugly. Menopause. 2008;15(4 Pt 1):581-582. PMID: 18551083
• Gertz ER, Silverman NE, Wise KS, Hanson KB, Alekel DL, Stewart JW, Perry CD, Bhupathiraju SN, Kohut ML, Van Loan MD. Contribution of serum inflammatory markers to changes in bone mineral content and density in postmenopausal women: a 1-year investigation. J Clin Densitom. 2010;13(3):277-82. PMID: 20605499
• Matvienko OA, Alekel DL, Bhupathiraju SN, Hofmann H, Ritland LM, Reddy MB, Van Loan MD, Perry CD. Androidal fat dominates in predicting cardiometabolic risk in postmenopausal women. Cardiol Res Pract. 2010;2011:904878. PMID: 21197412
• Bhupathiraju SN, Tucker KL. Greater variety in fruit and vegetable intake is associated with lower inflammation in Puerto Rican adults. Am J Clin Nutr. 2011;93(1):37-46. PMID: 21068354.
• Bhupathiraju SN, Lichtenstein AH, Dawson-Hughes B, Tucker KL. Adherence index based on the AHA 2006 diet and lifestyle recommendations is associated with select cardiovascular disease risk factors in older Puerto Ricans. J Nutr. 2011;141(3):460-9. PMID: 21270369.
• Bhupathiraju SN, Lichtenstein AH, Dawson-Hughes B, Hannan MT, Tucker KL. Adherence to the 2006 American Heart Association Diet and Lifestyle Recommendations for cardiovascular disease risk reduction is associated with bone health in older Puerto Ricans. Am J Clin Nutr. 2013;98(5):1309-16. PMID: 21270369.
• Hermsdorff HH, Zulet MÁ, Martínez JA. The implication of unknown bioactive compounds and cooking techniques in relations between the variety in fruit and vegetable intake and inflammation. Am J Clin Nutr. 2011;93(6):1384. Author reply 1384-5. PMID: 21450936
• Bhupathiraju SN, Dawson-Hughes B, Hannan MT, Lichtenstein AH, Tucker KL. Centrally located body fat is associated with lower bone mineral density in older Puerto Rican adults. Am J Clin Nutr. 2011;94(4):1063-70. PMID: 21865328.
• Bhupathiraju SN, Pan A, Malik VS, Manson JE, Willett WC, van Dam RM, Hu FB. Caffeinated and caffeine-free beverages and risk of type 2 diabetes. Am J Clin Nutr. 2013;97(1):155-66. PMID: 23151535.
• Ye X, Bhupathiraju SN, Tucker KL. Variety in fruit and vegetable intake and cognitive function in middle-aged and older Puerto Rican adults. Br J Nutr. 2013;109(3):503-10. PMID: 22717056.
• Mitchell F. Diabetes: Drink coffee or tea to reduce risk of type 2 diabetes mellitus? Nat Rev Endocrinol. 2013; 9(2): 64. PMID: 23207837.
• Mattei J, Bhupathiraju S, Tucker KL. Higher adherence to a diet score based on American Heart Association recommendations is associated with lower odds of allostatic load and metabolic syndrome in Puerto Rican adults. J Nutr. 2013;143(11):1753-59. PMID: 24005611.
• Bhupathiraju SN, Wedick NM, Pan A, Manson JE, Rexrode KM, Willett WC, Rimm EB, Hu FB. Quantity and variety in fruit and vegetable intake and risk of coronary heart disease. Am J Clin Nutr. 2013;98(6):1514-23.PMID: 24088718.
• Ding M, Bhupathiraju SN, Satija A, van Dam RM, Hu FB. Long-term coffee consumption and risk of cardiovascular disease: a systematic review and a dose-response meta-analysis of prospective cohort studies. Circulation. 2014;129(6):643-59. PMID: 24201300.
• Chanson P, The more cups of coffee, caffeinated or decaffeinated, the greater risk of type 2 diabetes. Rev Prat2014;64(2):183. PMID: 24701876.
• Ding M, Bhupathiraju SN, Chen M, van Dam RM, Hu FB. Caffeinated and decaffeinated coffee consumption and risk of type 2 diabetes: a systematic review and a dose-response meta-analysis. Diabetes Care. 2014;37(2):569-86. PMID: 24459154.
• Bhupathiraju SN, Pan A, Manson JE, Willett WC, van Dam RM, Hu FB. Changes in coffee intake and subsequent risk of type 2 diabetes: three large cohorts of US men and women. Diabetologia. 2014;57(7):1346-54. PMID: 24771089.
• Raben A, Glycemic index and metabolic risks: how strong is the evidence? Am J Clin Nutr. 2014;100(1):1-3. PMID: 24898238.
• Bhupathiraju SN, Tobias DK, Malik VS, Pan A, Hruby A, Manson JE, Willett WC, Hu FB. Glycemic index, glycemic load, and risk of type 2 diabetes: results from 3 large US cohorts and an updated meta-analysis. Am J Clin Nutr. 2014;100(1):218-32. PMID: 24787496.
• Hu Y, Bhupathiraju SN, de Koning L, Hu FB. Duration of obesity and overweight and risk of type 2 diabetes among US women. Obesity (Silver Spring). 2014;22(10):2267-73. PMID: 25131512.
• Sotos-Prieto M, Bhupathiraju SN, Falcon LM, Gao X, Tucker KL, Mattei J. A Healthy Lifestyle Score Is Associated with Cardiometabolic and Neuroendocrine Risk Factors among Puerto Rican Adults. J Nutr. 2015;145(7):1531-40. PMID: 25948783.
• Gregg EW, Albright A. Compelling evidence linking sugary drinks with diabetes. BMJ. 2015;351:h4087. PMID: 26224343.
• Imamura F, O'Connor L, Ye Z, Mursu J, Hayashino Y, Bhupathiraju SN, Forouhi NG. Consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of type 2 diabetes: systematic review, meta-analysis, and estimation of population attributable fraction. BMJ.2015;351:h3576. PMID: 26199070
• AlEssa HB, Bhupathiraju SN, Malik VS, Wedick NM, Campos H, Rosner B, Willett WC, Hu FB. Carbohydrate quality and quantity and risk of type 2 diabetes in US women. Am J Clin Nutr. 2015;102(6):1543-53.  PMID: 26537938.
• Sotos-Prieto M, Bhupathiraju SN, Mattei J, Fung TT, Li Y, Pan A, Willett WC, Rimm EB, Hu FB. Changes in Diet Quality Scores and Risk of Cardiovascular Disease Among US Men and Women. Circulation. 2015;132(24):2305-15.  PMID: 26644246.
• Ding M, Satija A, Bhupathiraju SN, Hu Y, Sun Q, Han J, Lopez-Garcia E, Willett W, van Dam RM, Hu FB. Association of Coffee Consumption With Total and Cause-Specific Mortality in 3 Large Prospective Cohorts. Circulation. 2015;132(24):2305-15. PMID: 26572796.
• Cespedes EM, Bhupathiraju SN, Li Y, Rosner B, Redline S, Hu FB. Long-term changes in sleep duration, energy balance and risk of type 2 diabetes. Diabetologia. 2016;59(1):101-109. PMID: 26522276.
• Sotos-Prieto M, Bhupathiraju SN, Falcon LM, Gao X, Tucker KL, Mattei J. Association between a Healthy Lifestyle Score and inflammatory markers among Puerto Rican adults. Nutr Metab Cardiovasc Dis. 2016;26(3):178-84. PMID: 26838054.
• Ding M, Satija A, Bhupathiraju SN, Hu Y, Sun Q, Han J, Lopez-Garcia E, Willett W, van Dam RM, Hu FB. Response to Letter Regarding Article, "Association of Coffee Consumption With Total and Cause-Specific Mortality in 3 Large Prospective Cohorts". Circulation. 2016;133(20):e660. PMID: 27185029.
• Satija A, Bhupathiraju SN, Rimm EB, Spiegelman D, Chiuve SE, Borgi L, Willett WC, Manson JE, Sun Q, Hu FB. Plant-Based Dietary Patterns and Incidence of Type 2 Diabetes in US Men and Women: Results from Three Prospective Cohort Studies.PLoS Med. 2016;13(6):e1002039. PubMed PMID: 27299701.
• Hu PJ, Ley SH, Bhupathiraju SN, Li Y, Wang DD. Associations of dietary, lifestyle, and sociodemographic factors with iron status in Chinese adults: a cross-sectional study in the China Health and Nutrition Survey. Am J Clin Nutr. 2017;105(2):503-512. PubMed PMID: 28031193.
• Sotos-Prieto M, Bhupathiraju SN, Mattei J, Fung TT, Li Y, Pan A, Willett WC, Rimm EB, Hu FB. Association of changes in diet quality with total and cause-specific mortality. N Engl J Med. 2017;377(13):1304-5. PMID: 28700845.
• Satija A, Bhupathiraju SN, Spiegelman D, Chiuve SE, Manson JE, Willett WC, Rexrode KM, Rimm EB, Hu FB. Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults. J Am Coll Cardiol. 2017;70(4):411-22. PMID: 28728684.
• Bhupathiraju SN, Grodstein F, Rosner BA, Stampfer MJ, Hu FB, Willett WC, Manson JE. Hormone therapy use and risk of chronic disease in the Nurses’Health Study: A Comparative Analysis with the Women’s Health Initiative. Am J Epidemiol. 2017;186(6):696-708. PMID: 28938710.
• Sotos-Prieto M, Bhupathiraju SN, Hu FB. Changes in diet quality and total and cause-specific mortality. N Engl J Med. 2017;377(13):1304-5. PMID: 28953436.
• Guasch-Ferré M, Liu X, Malik VS, Sun Q, Willett WC, Manson JE, Rexrode KM, Li Y, Hu FB, Bhupathiraju SN. Nut consumption and risk of cardiovascular disease. J Am Coll Cardiol 2017;70(20):2519-2532. PMID: 29145952.
• Hruby A, Guasch-Ferré M, Bhupathiraju SN, Manson JE, Willett WC, McKeown NM, Hu FB. Magnesium Intake, Quality of Carbohydrates, and Risk of Type 2 Diabetes: Results From Three U.S. Cohorts. Diabetes Care. 2017. pii: dc171143. PMID: 28978672.
• Bhupathiraju SN. Guasch- Ferré M, Gadgil MD, Newgard CB, Bain JR, Muehlbauer MJ, Ilkayeva OR, Scholtens DM, Hu FB, Kanaya AM, Kandula NR. Dietary Patterns among Asian Indians Living in the United States have Distinct Metabolomic Profiles That Are Associated with Cardiometabolic Risk. J Nutr2018;148(7):1150-59.
• Shan Z, Li Y, Zong G, Guo Y, Li J, Manson JE, Hu FB, Willett WC, Schernhammer ES, Bhupathiraju SN. Rotating night shift work and adherence to unhealthy lifestyle in predicting type 2 diabetes risk: Results from two large US cohorts of female nurses. BMJ 2018;363:k4641. PMID: 30464025.
• Bhupathiraju SN, Grodstein F, Stampfer MJ, Willett WC, Crandall CJ, Shifren JL, Manson JE. Vaginal estrogen use and chronic disease risk in the Nurses' Health Study. Menopause. 2018;26(6):603-610. PMID: 30562320.
• Shan Z, Bhupathiraju SN. Authors' reply to Skovenborg and Manfredini and colleagues. BMJ. 2019;364:l179.
• Baden YM, Liu G, Satija A, Li Y, Sun Q, Fung TT, Rimm EB, Willett WC, Hu FB, Bhupathiraju SN. Changes in plant-based diet quality and total and cause-specific mortality. Circulation. 2019; 140: 979-991. PMID: 31401846.
• Liu X, Li Y, Guasch-Ferré M, Willett WC, Drouin-Chartier JP, Bhupathiraju SN, Tobias DK. Changes in nut consumption influence long-term weight change in US men and women. BMJ NutrPrev Health. 2019 Sep 23;2(2):90-99. doi: 10.1136/bmjnph-2019-000034. PMID: 33235963; PMCID: PMC7664489.
• Shan Z, Rehm CD, Rogers G, Ruan M, Wang DD, Hu FB, Mozaffarian D, Zhang FF, Bhupathiraju SN. Trends in Dietary Carbohydrate, Protein, and Fat Intake and Diet Quality Among US Adults, 1999-2016. JAMA. 2019 Sep 24;322(12):1178-1187. PMID: 31550032; PMCID: PMC6763999.
• Qian F, Liu G, Hu FB, Bhupathiraju SN, Sun Q. Association Between Plant- Based Dietary Patterns and Risk of Type 2 Diabetes: A Systematic Review and Meta-analysis. JAMA Intern Med. 2019 Oct 1;179(10):1335-1344. PMID: 31329220; PMCID: PMC6646993.
• Chiu YH, Sandoval-Insausti H, Ley SH, Bhupathiraju SN, Hauser R, Rimm EB, Manson JE, Sun Q, Chavarro JE. Association between intake of fruits and vegetables by pesticide residue status and coronary heart disease risk. Environ Int. 2019 Nov;132:105113. PMID: 31473415; PMCID: PMC6754761.
• Drouin-Chartier JP, Zheng Y, Li Y, Malik V, Pan A, Bhupathiraju SN, Tobias DK, Manson JE, Willett WC, Hu FB. Changes in Consumption of Sugary Beverages and Artificially Sweetened Beverages and Subsequent Risk of Type 2 Diabetes: Results From Three Large Prospective U.S. Cohorts of Women and Men. Diabetes Care. 2019 Dec;42(12):2181-2189. PMID: 31582428; PMCID: PMC6868459.
• Palacios N, Lee JS, Scott T, Kelly RS, Bhupathiraju SN, Bigornia SJ, Tucker KL. Circulating Plasma Metabolites and Cognitive Function in a Puerto Rican Cohort. J Alzheimers Dis. 2020;76(4):1267-1280. PMID: 32716356; PMCID: PMC8061579.
• Drouin-Chartier JP, Chen S, Li Y, Schwab AL, Stampfer MJ, Sacks FM, Rosner B, Willett WC, Hu FB, Bhupathiraju SN. Egg consumption and risk of cardiovascular disease: three large prospective US cohort studies, systematic review, and updated meta-analysis. BMJ. 2020 Mar 4;368:m513. PMID: 32132002; PMCID: PMC7190072.
• Liu X, Guasch-Ferré M, Drouin-Chartier JP, Tobias DK, Bhupathiraju SN, Rexrode KM, Willett WC, Sun Q, Li Y. Changes in Nut Consumption and Subsequent Cardiovascular Disease Risk Among US Men and Women: 3 Large Prospective Cohort Studies. J Am Heart Assoc. 2020 Apr 7;9(7):e013877. PMID: 32233756; PMCID: PMC7428648.
• Zhou B, Ichikawa R, Parnell LD, Noel SE, Zhang X, Bhupathiraju SN, Smith CE, Tucker KL, Ordovas JM, Lai CQ. Metabolomic Links between Sugar-Sweetened Beverage Intake and Obesity. J Obes. 2020 Apr 13;2020:7154738. PMID: 32399287; PMCID: PMC7211252.
• Ding M, Ahmad S, Qi L, Hu Y, Bhupathiraju SN, Guasch-Ferré M, Jensen MK, Chavarro JE, Ridker PM, Willett WC, Chasman DI, Hu FB, Kraft P. Additive and Multiplicative Interactions Between Genetic Risk Score and Family History and Lifestyle in Relation to Risk of Type 2 Diabetes. Am J Epidemiol. 2020 May 5;189(5):445-460. Erratum in: Am J Epidemiol. 2020 May 5;189(5):483. PMID: 31647510; PMCID: PMC7462250.
• Haslam DE, Li J, Liang L, Martinez M, Palacios C, Trak-Fellermeier MA, Franks PW, Joshipura K, Bhupathiraju SN. Changes in Metabolites During an Oral Glucose Tolerance Test in Early and Mid-Pregnancy: Findings from the PEARLS Randomized, Controlled Lifestyle Trial. Metabolites. 2020 Jul 10;10(7):284. PMID: 32664282; PMCID: PMC7408149.
• Li J, Guasch-Ferré M, Chung W, Ruiz-Canela M, Toledo E, Corella D, Bhupathiraju SN, Tobias DK, Tabung FK, Hu J, Zhao T, Turman C, Feng YA, Clish CB, Mucci L, Eliassen AH, Costenbader KH, Karlson EW, Wolpin BM, Ascherio A, Rimm EB, Manson JE, Qi L, Martínez-González MÁ, Salas-Salvadó J, Hu FB, Liang L. The Mediterranean diet, plasma metabolome, and cardiovascular disease risk. Eur Heart J. 2020 Jul 21;41(28):2645-2656. PMID: 32406924; PMCID: PMC7377580.
• Shan Z, Li Y, Baden MY, Bhupathiraju SN, Wang DD, Sun Q, Rexrode KM, Rimm EB, Qi L, Willett WC, Manson JE, Qi Q, Hu FB. Association Between Healthy Eating Patterns and Risk of Cardiovascular Disease. JAMA Intern Med. 2020 Aug 1;180(8):1090-1100. PMID: 32539102; PMCID: PMC7296454.
• Drouin-Chartier JP, Schwab AL, Chen S, Li Y, Sacks FM, Rosner B, Manson JE, Willett WC, Stampfer MJ, Hu FB, Bhupathiraju SN. Egg consumption and risk of type 2 diabetes: findings from 3 large US cohort studies of men and women and a systematic review and meta-analysis of prospective cohort studies. Am J Clin Nutr. 2020 Sep 1;112(3):619-630. PMID: 32453379; PMCID: PMC7458776.
• Murthy VL, Yu B, Wang W, Zhang X, Alkis T, Pico AR, Yeri A, Bhupathiraju SN, Bressler J, Ballantyne CM, Freedman JE, Ordovas J, Boerwinkle E, Tucker KL, Shah R. Molecular Signature of Multisystem Cardiometabolic Stress and Its Association With Prognosis. JAMA Cardiol. 2020 Oct 1;5(10):1144-1153. PMID: 32717046; PMCID: PMC7376474.
• Li J, Lee DH, Hu J, Tabung FK, Li Y, Bhupathiraju SN, Rimm EB, Rexrode KM, Manson JE, Willett WC, Giovannucci EL, Hu FB. Dietary Inflammatory Potential and Risk of Cardiovascular Disease Among Men and Women in the U.S. J Am Coll Cardiol. 2020 Nov 10;76(19):2181-2193. PMID: 33153576; PMCID: PMC7745775.
• Guasch-Ferré M, Hernández-Alonso P, Drouin-Chartier JP, Ruiz-Canela M, Razquin C, Toledo E, Li J, Dennis C, Wittenbecher C, Corella D, Estruch R, Fitó M, Ros E, Babio N, Bhupathiraju SN, Clish CB, Liang L, Martínez-González MA, Hu FB, Salas-Salvadó J. Walnut Consumption, Plasma Metabolomics, and Risk of Type 2 Diabetes and Cardiovascular Disease. J Nutr. 2021 Feb 1;151(2):303-311. PMID: 33382410; PMCID: PMC7850062.
• Chen Z, Drouin-Chartier JP, Li Y, Baden MY, Manson JE, Willett WC, Voortman T, Hu FB, Bhupathiraju SN. Changes in Plant-Based Diet Indices and Subsequent Risk of Type 2 Diabetes in Women and Men: Three U.S. Prospective Cohorts. Diabetes Care. 2021 Mar;44(3):663-671. PMID: 33441419; PMCID: PMC7896264.
• Wang DD, Li Y, Bhupathiraju SN, Rosner BA, Sun Q, Giovannucci EL, Rimm EB, Manson JE, Willett WC, Stampfer MJ, Hu FB. Fruit and Vegetable Intake and Mortality: Results From 2 Prospective Cohort Studies of US Men and Women and a Meta-Analysis of 26 Cohort Studies. Circulation. 2021 Apr 27;143(17):1642-1654. PMID: 33641343; PMCID: PMC8084888.
• Haslam DE, Liang L, Wang DD, Kelly RS, Wittenbecher C, Pérez CM, Martínez M, Lee CH, Clish CB, Wong DTW, Parnell LD, Lai CQ, Ordovás JM, Manson JE, Hu FB, Stampfer MJ, Tucker KL, Joshipura KJ, Bhupathiraju SN. Associations of network- derived metabolite clusters with prevalent type 2 diabetes among adults of Puerto Rican descent. BMJ Open Diabetes Res Care. 2021 Aug;9(1):e002298. PMID: 34413117; PMCID: PMC8378385.
• Parnell LD, Noel SE, Bhupathiraju SN, Smith CE, Haslam DE, Zhang X, Tucker KL, Ordovas JM, Lai CQ. Metabolite patterns link diet, obesity, and type 2 diabetes in a Hispanic population. Metabolomics. 2021 Sep 22;17(10):88. PMID: 34553271; PMCID: PMC8458177.
• Birk N, Matsuzaki M, Fung TT, Li Y, Batis C, Stampfer MJ, Deitchler M, Willett WC, Fawzi WW, Bromage S, Kinra S, Bhupathiraju SN, Lake E. Exploration of Machine Learning and Statistical Techniques in Development of a Low-Cost Screening Method Featuring the Global Diet Quality Score for Detecting Prediabetes in Rural India. J Nutr. 2021 Oct 23;151(12 Suppl 2):110S-118S. PMID: 34689190; PMCID: PMC8542097.
• Bromage S, Batis C, Bhupathiraju SN, Fawzi WW, Fung TT, Li Y, Deitchler M, Angulo E, Birk N, Castellanos-Gutiérrez A, He Y, Fang Y, Matsuzaki M, Zhang Y, Moursi M, Gicevic S, Holmes MD, Isanaka S, Kinra S, Sachs SE, Stampfer MJ, Stern D, Willett WC. Development and Validation of a Novel Food-Based Global Diet Quality Score (GDQS). J Nutr. 2021 Oct 23;151(12 Suppl 2):75S-92S. PMID: 34689200; PMCID: PMC8542096.
• He Y, Fang Y, Bromage S, Fung TT, Bhupathiraju SN, Batis C, Deitchler M, Fawzi W, Stampfer MJ, Hu FB, Willett WC, Li Y. Application of the Global Diet Quality Score in Chinese Adults to Evaluate the Double Burden of Nutrient Inadequacy and Metabolic Syndrome. J Nutr. 2021 Oct 23;151(12 Suppl 2):93S-100S. PMID: 34689199; PMCID: PMC8542094.
• Bromage S, Andersen CT, Tadesse AW, Passarelli S, Hemler EC, Fekadu H, Sudfeld CR, Worku A, Berhane H, Batis C, Bhupathiraju SN, Fung TT, Li Y, Stampfer MJ, Deitchler M, Willett WC, Fawzi WW. The Global Diet Quality Score is Associated with Higher Nutrient Adequacy, Midupper Arm Circumference, Venous Hemoglobin, and Serum Folate Among Urban and Rural Ethiopian Adults. J Nutr. 2021 Oct 23;151(12 Suppl 2):130S-142S. PMID: 34689198; PMCID: PMC8564694.
• Bromage S, Zhang Y, Holmes MD, Sachs SE, Fanzo J, Remans R, Sachs JD, Batis C, Bhupathiraju SN, Fung TT, Li Y, Stampfer MJ, Deitchler M, Willett WC, Fawzi WW. The Global Diet Quality Score Is Inversely Associated with Nutrient Inadequacy, Low Midupper Arm Circumference, and Anemia in Rural Adults in Ten Sub-Saharan African Countries. J Nutr. 2021 Oct 23;151(12 Suppl 2):119S-129S. PMID: 34689197; PMCID: PMC8542095.
• Fung TT, Li Y, Bhupathiraju SN, Bromage S, Batis C, Holmes MD, Stampfer M, Hu FB, Deitchler M, Willett WC. Higher Global Diet Quality Score Is Inversely Associated with Risk of Type 2 Diabetes in US Women. J Nutr. 2021 Oct 23;151(12 Suppl 2):168S-175S. PMID: 34689196; PMCID: PMC8542093.
• Castellanos-Gutiérrez A, Rodríguez-Ramírez S, Bromage S, Fung TT, Li Y, Bhupathiraju SN, Deitchler M, Willett W, Batis C. Performance of the Global Diet Quality Score with Nutrition and Health Outcomes in Mexico with 24-h Recall and FFQ Data. J Nutr. 2021 Oct 23;151(12 Suppl 2):143S-151S. PMID: 34689195; PMCID: PMC8542100.
• Angulo E, Stern D, Castellanos-Gutiérrez A, Monge A, Lajous M, Bromage S, Fung TT, Li Y, Bhupathiraju SN, Deitchler M, Willett WC, Batis C. Changes in the Global Diet Quality Score, Weight, and Waist Circumference in Mexican Women. J Nutr. 2021 Oct 23;151(12 Suppl 2):152S-161S. PMID: 34689194; PMCID: PMC8542099.
• Moursi M, Bromage S, Fung TT, Isanaka S, Matsuzaki M, Batis C, Castellanos- Gutiérrez A, Angulo E, Birk N, Bhupathiraju SN, He Y, Li Y, Fawzi W, Danielyan A, Thapa S, Ndiyoi L, Vossenaar M, Bellows A, Arsenault JE, Willett WC, Deitchler M. There's an App for That: Development of an Application to Operationalize the Global Diet Quality Score. J Nutr. 2021 Oct 23;151(12 Suppl 2):176S-184S. PMID: 34689193; PMCID: PMC8542098.
• Fung TT, Li Y, Bromage S, Bhupathiraju SN, Batis C, Fawzi W, Holmes MD, Stampfer M, Hu FB, Deitchler M, Willett WC. Higher Global Diet Quality Score Is Associated with Less 4-Year Weight Gain in US Women. J Nutr. 2021 Oct 23;151(12 Suppl 2):162S-167S. PMID: 34689192; PMCID: PMC8542092.
• Matsuzaki M, Birk N, Bromage S, Bowen L, Batis C, Fung TT, Li Y, Stampfer MJ, Deitchler M, Willett WC, Fawzi WW, Kinra S, Bhupathiraju SN. Validation of Global Diet Quality Score Among Nonpregnant Women of Reproductive Age in India: Findings from the Andhra Pradesh Children and Parents Study (APCAPS) and the Indian Migration Study (IMS). J Nutr. 2021 Oct 23;151(12 Suppl 2):101S-109S. PMID: 34689191; PMCID: PMC8564710.
• Merino J, Joshi AD, Nguyen LH, Leeming ER, Mazidi M, Drew DA, Gibson R, Graham MS, Lo CH, Capdevila J, Murray B, Hu C, Selvachandran S, Hammers A, Bhupathiraju SN, Sharma SV, Sudre C, Astley CM, Chavarro JE, Kwon S, Ma W, Menni C, Willett WC, Ourselin S, Steves CJ, Wolf J, Franks PW, Spector TD, Berry S, Chan AT. Diet quality and risk and severity of COVID-19: a prospective cohort study. Gut. 2021 Nov;70(11):2096-2104. PMID: 34489306; PMCID: PMC8500931.
• Mendoza-Herrera K, Florio AA, Moore M, Marrero A, Tamez M, Bhupathiraju SN, Mattei J. The Leptin System and Diet: A Mini Review of the Current Evidence. Front Endocrinol (Lausanne). 2021 Nov 24;12:749050. PMID: 34899599; PMCID: PMC8651558.
• Clark O, Lee MM, Jingree ML, O'Dwyer E, Yue Y, Marrero A, Tamez M, Bhupathiraju SN, Mattei J. Weight Stigma and Social Media: Evidence and Public Health Solutions. Front Nutr. 2021 Nov 12;8:739056. PMID: 34869519; PMCID: PMC8632711.
• Merino J, Joshi AD, Nguyen LH, Leeming ER, Mazidi M, Drew DA, Gibson R, Graham MS, Lo CH, Capdevila J, Murray B, Hu C, Selvachandran S, Hammers A, Bhupathiraju SN, Sharma SV, Sudre C, Astley CM, Chavarro JE, Kwon S, Ma W, Menni C, Willett WC, Ourselin S, Steves CJ, Wolf J, Franks PW, Spector TD, Berry S, Chan AT. Diet quality and risk and severity of COVID-19: a prospective cohort study. Gut. 2021 Nov;70(11):2096-2104. doi: 10.1136/gutjnl-2021-325353. PMID: 34489306 
• Chen Z, Qian F, Liu G, Li M, Voortman T, Tobias DK, Ley SH, Bhupathiraju SN, Li LJ, Chavarro JE, Sun Q, Hu FB, Zhang C. Prepregnancy plant-based diets and the risk of gestational diabetes mellitus: a prospective cohort study of 14,926 women. Am J Clin Nutr. 2021 Sep 12;114(6):1997–2005. PMID: 34510175; PMCID: PMC8634573.
• Wittenbecher C, Guasch-Ferré M, Haslam DE, Dennis C, Li J, Bhupathiraju SN, Lee CH, Qi Q, Liang L, Eliassen AH, Clish C, Sun Q, Hu FB. Changes in metabolomics profiles over ten years and subsequent risk of developing type 2 diabetes: Results from the Nurses' Health Study. EBioMedicine. 2022;75:103799. PMID: 34979341; PMCID: PMC8733263.
• Jaacks LM, Awasthi A, Bhupathiraju S, Kumar S, Gupta S, Sonawane V. A Community-Based Noncommunicable Disease Prevention Intervention in Punjab, India: Baseline Characteristics of 11,322 Adults. Indian J Community Med. 2022 (In Press). PMID: 35368473.
• Sandoval-Insausti H, Chiu YH, Wang YX, Hart JE, Bhupathiraju SN, Mínguez- Alarcón L, Ding M, Willett WC, Laden F, Chavarro JE. Intake of fruits and vegetables according to pesticide residue status in relation to all-cause and disease-specific mortality: Results from three prospective cohort studies. Environ Int. 2022 Jan 15;159:107024. PMID: 34894487.
• Kim J, Bhupathiraju SN, Harrington LB, Hagan KA, Lindström S, Manson JE, Kraft P, Kabrhel C. Oral postmenopausal hormone therapy and genetic risk on venous thromboembolism: gene-hormone interaction results from a large prospective cohort study. Menopause. 2022,29(3):293-303. PMID: 35013060.
• Ma W, Nguyen LH, Yue Y, Ding M, Drew DA, Wang K, Merino J, Rich-Edwards JW, Sun Q, Camargo CA, Giovannucci E, Willett W, Manson JE, Song M, Bhupathiraju SN*, Chan AT*. Associations between predicted vitamin D status, vitamin D intake, and risk of SARS-CoV-2 infection and Coronavirus Disease 2019 severity. Am J Clin Nutr. 2022 Apr 1;115(4):1123-1133. doi: 10.1093/ajcn/nqab389. PMID: 34864844; PMCID: PMC8690242.*co-senior authors
• Rivas-Tumanyan S, Pacheco LS, Haslam DE, Liang L, Tucker KL, Joshipura KJ, Bhupathiraju SN. Novel Plasma Metabolomic Markers Associated with Diabetes Progression in Older Puerto Ricans. Metabolites. 2022;12(6):513. PMID: 35736445.
• Guasch-Ferré M, Li Y, Bhupathiraju SN, Huang T, Drouin-Chartier JP, Manson JE, Sun Q, Rimm EB, Rexrode KM, Willett WC, Stampfer MJ, Hu FB. Healthy Lifestyle Score Including Sleep Duration and Cardiovascular Disease Risk. Am J Prev Med. 2022 Jul;63(1):33-42. PMID: 35361505.
• Wang F, Baden MY, Guasch-Ferré M, Wittenbecher C, Li J, Li Y, Wan Y, Bhupathiraju SN, Tobias DK, Clish CB, Mucci LA, Eliassen AH, Costenbader KH, Karlson EW, Ascherio A, Rimm EB, Manson JE, Liang L, Hu FB. Plasma metabolite profiles related to plant-based diets and the risk of type 2 diabetes. Diabetologia. 2022 Jul;65(7):1119-1132. PMID: 35391539
• Haslam DE, Li J, Cao Y, Zeleznik, Eliassen AH, Liang L, Stampfer MJ, Mora S, Chen ZZ, Gerszten RE, Hu FB, Chan AT, Bhupathiraju SN. Stability and reproducibility of proteomic profiles among men and women using the Olink platform. Proteomics. 2022 Jul;22(13-14):e2100170.PMID: 35598103.
• Yu J, Balaji B, Tinajero M, Jarvis S, Khan T, Vasudevan S, Ranawana V, Poobalan A, Bhupathiraju S, Sun Q, Willett W, Hu FB, Jenkins DJA, Mohan V, Malik VS. White rice, brown rice and the risk of type 2 diabetes: a systematic review and meta-analysis. BMJ Open. 2022; 12(9): e065426.
• Bhupathiraju SN, Sawicki CM, Goon S, Gujral UP, Hu FB, Kandula NR, Kanaya AM. A healthy plant-based diet is favorably associated with cardiometabolic risk factors among participants of South Asian ancestry. Am J Clin Nutr. 2022  Oct 6;116(4):1078-1090. doi: 10.1093/ajcn/nqac174. PMID: 35731596.
• Yue Y, Ma W, Accorsi EK, Ding M, Hu F, Willett WC, Chan AT, Sun Q, Edwards JR, Smith-Warner SA, Bhupathiraju SN. Long-term diet and risk of SARS -CoV-2 infection and Coronavirus Disease 2019 (COVID-19) severity. Am J Clin Nutr. 2022 Dec 19;116(6):1672-1681. doi: 10.1093/ajcn/nqac219. PMID: 35945354.
• De Ville NV, Iyer HS, Holland I, Bhupathiraju SN, Chai B, James P, Kawachi I, Laden F, Hart JE. Neighborhood socioeconomic status and mortality in the Nurses’ Health Study (NHS) and the Nurses’ Health Study II (NHS II). Environmental Epidemiology 2022 Dec 14;7(1):e235. 
• Yang J, Tobias DK, Li S, Bhupathiraju SN, Ley SH, Hinkle SN, Qian F, Chen Z, Zhu Y, Bao W, Chavarro J, Hu FB, Zhang C. Habitual coffee consumption and subsequent risk of type 2 diabetes in individuals with a history of gestational diabetes – a prospective study of 88809 person-years of follow-up. Am J Clin Nutr. 2022116(6):1693-1703. PMID: 36373514.
• Priya NL, Gayathri R, Bhupathiraju S, Vasudevan K, Veeramarthandan R, Krishnaswamy K, Mohan AR, Unnikrishnan R, Mohan V, Vasudevan S. Identification of Dietary Patterns Associated with Poor Glycemic Control among Free Living Adults with Type 2 Diabetes in Chennai (CURES-162). Journal of Diabetology 2022; 1(10): 71-82.
• Shan Z, Wang F, Li Y, Baden MY, Bhupathiraju SN, Wang DD, Sun Q, Rexrode KM, Rimm EB, Qi L, Tabung FK, Giovannucci EL, Willett WC, Manson JE, Qi Q, Hu FB. Healthy Eating Patterns and Risk of Total and Cause-Specific Mortality. JAMA Intern Med. 2023: e226117 (In Press). PMID: 36622660.
• Ma W, Murray E, Nguyen LH, Drew DA, Ding M, Stopsack KH, Rich-Edwards JW, Hart JE, Figueiredo JC, Lacey JV, Patel AV, Bhupathiraju SN, Chan AT, Martinez ME. Physical Activity, Sedentary Behavior, and Risk of Coronavirus Disease 2019. Am J Med. 2023 Am J Med. 2023 Jun;136(6):568-576.e3. doi: 10.1016/j.amjmed.2022.12.029.PMID: 36657558.
• Rai KS, Gortmaker SL, Hu FB, Kanaya AM, Kandula NR, Sun Q, Bhupathiraju SN. A South Asian Mediterranean-style diet pattern is associated with favorable measures of adiposity and a lower risk of incident diabetes: Findings from the MASALA study. Obesity Obesity (Silver Spring). 2023 Jun;31(6):1697-1706.
• Wang X, Hu Y, Menichetti G, Grodstein F, Bhupathiraju SN, Sun Q, Zhang X, Hu FB, Weiss ST, Liu YY. Nutritional redundancy in the human diet and its application in phenotype association studies. Nature Communications 2023 Jul 18;14(1):4316. PMID: 37463879 
• Sawicki CM, Haslam DE, Braun KVE, Drouin-Chartier JP, Voortman T, Franco OH, Sun Q, Hu FB, Bhupathiraju SN. Methyl Donor Nutrient Intake and Incidence of Type 2 Diabetes: Results From Three Large U.S. Cohorts.  Diabetes Care 2023 Oct 1;46(10):1799-1806.  doi: 10.2337/dc23-0662. PMID: 37643330
• Iman MN, Haslam DE, Liang L, Guo K, Joshipura K, Perez CM, Clish C, Tucker KL, Manson JE, Fukusaki E, Lasky-Su J*, Bhupathiraju SN*, Putri SP*. Bringing food metabolomics and epidemiology together to understand the association of meglutol with cardiometabolic risk. Food Chemistry (submitted). *co-senior authors
• Haslam DE, Liang L, Guo K, Martinez-Lozano M, Perez CM, Lee CH, Morou-Bermudez E, Clish C, Wong DTW, Manson JE, Hu FB, Stampfer MJ, Joshipura K, Bhupathiraju SN. Discovery and validation of plasma, saliva, and multi-fluid plasma-saliva metabolomic profiles of insulin resistance and diabetes progression or regression among Puerto Rican adults. Diabetologia (resubmited)  
• Sawicki CM, Ren Y, Kanaya AM, Kandula N, Gadgil M, Liang L, Haslam DE, Bhupathiraju SN. Metabolite profiles of plant-based diets and cardiometabolic risk in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study. Diabetologia (submitted)
• Nair NK, Bui LP, Sawicki CM, Kandula NR, Kanaya AM, Lee KH, Stampfer M, Willett WC, Bhupathiraju SN. Development and Validation of a Planetary Health Diet Index:  The Mediators of Atherosclerosis in South Asians Living in America. Journal of the Academy of Nutrition and Dietetics (under review)
• Nair NK, Bui LP, Sawicki CM, Kandula NR, Kanaya AM, Lee KH, Stampfer M, Willett WC, Bhupathiraju SN. Adherence to the EAT-Lancet Planetary Health Diet and Cardiometabolic Risk Markers in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study. Circulation (submitted)
• Sotos-Prieto M, Rodriguez-Artalejo F, Meyer HE, Fung TT, Hu FB, Willett W, Bhupathiraju SN. Plant-Based Diets and Risk of Hip Fracture in Postmenopausal Women. JAMA Network Open (Accepted)
• Pacheco LS, Tobias DK, Li Y, Bhupathiraju SN, Willett WC, Ludwig DS, Ebbeling CB, Haslam DE, Drouin-Chartier JP, Hu FB, Guasch-Ferré M. Sugar-sweetened or artificially sweetened beverage consumption, physical activity, and risk of cardiovascular disease in adults: a prospective cohort study. Am J Clin Nutr (In Press). 2024 Jan 6:S0002-9165(24)00001-7. doi: 10.1016/j.ajcnut.2024.01.001. PMID: 38185281
• Sawicki, CM, Ramesh G, Bui L, Niar N, HuFB, Rimm EB, Stampfer MJ, Willett WC, Bhupathiraju SN. Planetary Health Diet and Cardiovascular Disease: Results from Three Large Prospective U.S. Cohort Studies. Nature Communications (under review)
• Wang Z, Haslam DE, Sawicki CM, Rivas-Tumanyan S,Hu F, Liang L, Wong DTW, Joshipura K, Bhupathiraju SN.Saliva, Plasma, and Multi-fluid Metabolomic Signatures of Periodontal Disease, Diabetes Progression, and Markers of Glycemia and Dyslipidemia Among Overweight and Obese Puerto Ricans. JAHA (revision submitted)
• Beasley JM, Hussain BM, Gadgil M, Talegawkar SA, Parekh N, Bhupathiraju S, Islam N, Kanaya AM. Dietary Patterns in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study: Comparisons Across Methodologies. BMJ Nutrition, Prevention, and Public Health (under review)
• Wang Z,  Sawicki CM, Haslam DE, Liang L, Wong DTW, Joshipura KJ, Hu FB, Chavarro J, Bhupathiraju SN.Saliva, Plasma, and Multi-fluid metabolic profiles of excess adiposity and their associations with diabetes progression among Puerto Ricans. Communications Medicine (under review)
• Johnson AF, Lamontagne N, Bhupathiraju SN, Brown AGM, Eicher-Miller HA, Fulgoni III VL, Rehm CD, Tucker KL, Woteki CE, Ohlhorst SD. Workshop summary: Building an NHANES for the Future. Am J Clin Nutr (Accepted)

• NUT 200 – Introduction to Nutrition Science
• NUT 201 – Introduction to Nutrition in Public Health
• ID 276 - Introduction to Nutrition Science