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Vivek Tanavde

Associate Professor
Ph.D.
Areas of interest
Adult Stem Cells, miRNA regulation of cell differentiation, Cancer biomarkers, connecting transcriptome to cellular phenotype.

Mentor: Venture Studio, Ahmedabad University, India.

Director & Scientific Advisory Board Member: iBioAnlaysis Pvt. Ltd. Ahmedabad, India.

Adjunct Principal Investigator: Bioinformatics Institute, Agency for Science Technology & Research (A*STAR), Biopolis, Singapore

 

Dr. Vivek Tanavde joined Ahmedabad Unviersity in 2017. Prior to this, he was a Principal Investigator at the Bioinformatics Institute, Singapore for more than 10 years. He was also heading the Hematopoietic Stem Cell Lab at Reliance Life Sciences, Mumbai where his work focused on developing mesenchymal stromal cell based therapies for cardiac and neuronal disorders. From 1999 to 2002 he was a post doctoral fellow with Dr. Curt Civin at the Sidney Kimmel Cancer Centre, Johns Hopkins University working on expansion of hematopoietic stem cells from umbilical cord blood. Dr. Tanavde obtained his Ph.D from the Cancer Research Institute, Mumbai (1999) in Applied Biology. He was also the Secretary of the Stem Cell Society, Singapore for 5 years & serves on the education committee of the International Society for Advancement of Cytometry (ISAC).

 

The focus of my group is to achieve targeted differentiation of Mesenchymal stromal cells (MSC) by regulating signaling pathways. MSC have the potential of differentiating into a variety of different cell types & therefore offer therapeutic potential to treat a variety of disorders. Therefore it is important to understand the precise mechanisms involved in MSC differentiation, how these mechanisms are regulated and how to manipulate these to achieve differentiation into the desired lineage.Previously we have identified signaling pathways critical for bone marrow derived MSC growth and differentiation (Ng Blood 2008) & miRNA networks that regulate signaling pathways in MSC (Koh BMC Genomics 2010). In the past few years my lab has focused on understanding the role of miRNAs in regulating MSC differentiation. Tools & approaches developed by our group for understanding MSC differentiation are also being used by our collaborators to understand embryonic stem cell (ESC) differentiation and the response of embryonic stem cells to toxins in the environment.

We are also interested in connecting the trasncriptome data to cellular phenotype. This is difficult but becoming increasingly important with the advent of Next Generation Sequencing (NGS) technologies. We can now generate accurate records of DNA sequence as well of the transcriptome with sensitivity to the single molecule level However what this data means and how this can help us interpret the cellular phenotype still remains a challenge. We have developed tools & approaches to solve this issue & sucessfuly connected transcriptome data to phenotypes in MSC (Guneta 2016, Takeda 2016), ESC (Wong 2016), skin cells (Sundaram 2013), hair follicles as well as developong zebrafish organs (Vaz 2016). 

Relevant Publications

  1. Guo J, Lin F, Zhang X, Tanavde V, Zheng J. (2017) NetLand: quantitative modeling and visualization of Waddington's epigenetic landscape using probabilistic potential.

Bioinformatics. 2017 Jan 19. pii: btx022. doi: 10.1093/bioinformatics/btx022.

  1. Guneta V, Tan NS, Chan SK, Tanavde V, Lim TC, Wong TC, Choong C. (2016) Comparative study of adipose-derived stem cells and bone marrow-derived stem cells in similar microenvironmental conditions. Exp Cell Res. 2016 Nov 1;348(2):155-164.

  1. Tkatchenko AV, Luo X, Tkatchenko TV, Vaz C, Tanavde VM, Maurer-Stroh S, Zauscher S, Gonzalez P, Young TL. (2016) Large-Scale microRNA Expression Profiling Identifies Putative Retinal miRNA-mRNA Signaling Pathways Underlying Form-Deprivation Myopia in Mice. PLoS One. 2016 Sep 13;11(9): e0162541.

  1. Takeda K, Sriram S, Chan XH, Ong WK, Yeo CR, Tan B, Lee SA, Kong KV, Hoon S, Jiang H, Yuen JJ, Perumal J, Agrawal M, Vaz C, So J, Shabbir A, Blaner WS, Olivo M, Han W, Tanavde V, Toh SA, Sugii S (2016). Retinoic Acid Mediates Visceral-Specific Adipogenic Defects of Human Adipose-Derived Stem Cells. Diabetes. 2016 May;65(5):1164-78. doi: 10.2337/db15-1315.

  1. Wong QW, Vaz C, Lee QY, Zhao TY, Luo R, Archer SK, Preiss T, Tanavde V, Vardy LA (2016). Embryonic Stem Cells Exhibit mRNA Isoform Specific Translational Regulation. PLoS One. 22; 11(1):e0143235. doi: 10.1371/journal.pone.0143235.

  1. Vaz C, Wee CW, Lee GP, Ingham PW, Tanavde V, Mathavan S. (2015) Deep sequencing of small RNA facilitates tissue and sex associated microRNA discovery in zebrafish. BMC Genomics. 2015 Nov 16;16:950.

  1. Tanavde V, Vaz C, Rao MS, Vemuri MC, Pochampally RR (2015). Research using Mesenchymal Stem/Stromal Cells: quality metric towards developing a reference material. Cytotherapy. 17(9):1169-7
  1. CandidaVaz, Choon Wei Wee, Serene Gek Ping Lee, Philip W Ingham, Vivek Tanavde, Sinnakaruppan Mathavan (2015). Deep sequencing of small RNA facilitates tissue and sex specific microRNA discovery in zebrafish. BMC Genomics. 16:950 DOI: 10.1186/s12864-015-2135-7
  1. Tanavde V, Vemuri MC, Pochampally R. Mesenchymal stromal cells: novel methods for characterization, understanding differentiation, and function (2014). Stem Cells Int. ;2014:630936.
  1. Sundaram GM, Common JE, Gopal FE, Srikanta S, Lakshman K, Lunny DP, Lim TC, Tanavde V, Lane EB, Sampath P. (2013) ‘See-saw' expression of microRNA-198 and FSTL1 from a single transcript in wound healing. Nature. 2013 Mar 7;495(7439):103-6.

  1. Chan XH, Nama S, Gopal F, Rizk P, Ramasamy S, Sundaram G, Ow GS, Ivshina AV, Tanavde V, Haybaeck J, Kuznetsov V, Sampath P. (2012) Targeting glioma stem cells by functional inhibition of a prosurvival oncomiR-138 in malignant gliomas. Cell Rep. 2012 Sep 27;2(3):591-602

  1. Zimmer B, Kuegler PB, Baudis B, Genewsky A, Tanavde V, Koh W, Tan B, Waldmann T, Kadereit S, Leist M. Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing. (2011). Cell Death Differ. 18(3):383-95.
  1. Ng F,.Boucher, S, Koh S, Sastry K. S., Chase L, Lakshmipathy U, Choong C, Yang Z, Vemuri M. C, Rao M. S, Tanavde, V.(2008) PDGF, TGF-b and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSC into adipogenic, chondrogenic and ostoegenic lineages. Blood. 112(2):295-307
  1. Vinod K Shah,Arvind J Desai,Jagdish B Vasvani,Mukesh M Desai,Bharat P Shah,Tilak K Lall,Manoj R Mashru,Kavita K Shalia, Vivek Tanavde, Satish S Desai, Bhavin J Jankharia (2007). Bone Marrow Cells for Myocardial Repair - A New Therapeutic Concept. Indian Heart Journal Dec 2007 482 - 490;

  1. P. Shetty, K. Bharucha, V. Tanavde (2007) Human umbilical cord blood serum can replace fetal bovine serum in the culture of mesenchymal stem cells. Cell Biol International 31.293-298.

  1. V Tanavde, M Malehorn, R Lumkul, Z Gao, J Wingard, E Garrett & Civin CI. (2002) Human stem-progenitor cells from neonatal cord blood have greater hematopoietic expansion capacity than those from mobilized adult blood. Exp. Hematol 30 pp:816-823.

  1. V.M. Tanavde, S.S. Desai & S.G.A. Rao (1997) Erythrocyte depletion of human umbilical cord blood using dextran sedimentation. Ind. J. Med Res. 106 pp:16-19.

  1. Rao, V.S. Chitnis, A. Deora, V. Tanavde and S.S. Desai (1996) An ICAM-1 like cell adhesion molecule is responsible for CD34 positive haemopoietic stem cell adhesion to bone marrow stroma. Cell Biol. Int 20 (4) pp: 255-259.

Relevant Book Chapters

  1. Vivek Tanavde and Mohan C Vemuri (2012) Mesenchymal; Stromal Cells in the Clinic: What Do the Clinical Trials Say? In: Mesenchymal Stem Cell Therapy, Lucas Chase & Mohan Vemuri (Eds), Humana Press.

  1. Vivek M Tanavde. (2011) Commercialization of Cord Blood. In: Umbilical Cord Stem Cells: A Future for Regenerative Medicine? Suzanne Kadereit, Gerald Udolph (eds.), World Scientific.

  1. Jyoti Kode and Vivek Tanavde. (2010) Flow cytometry as a tool to understand Mesenchymal Stromal Cells and explore their clinical applications. In: Flow Cytometry in Stem Cell Research and Tissue Regeneration, Awtar Krishan, H Krishnamurthy, Satish Totey (eds.), Wiley Blackwell.

  1. Vivek M. Tanavde, Lailing Liew, Jiahao Lim and Felicia Ng (2009) Signaling Networks in Mesenchymal Stem Cells. In: Regulatory Networks in Stem Cells, V.K. Rajasekhar, M.C. Vemuri (eds.), Humana Press.

Patents

“In-Vitro Culture of MSC and a Process for the Preparation Thereof", Patent granted in South Africa (No ZA200404101), 2005.

Winter 2017: Introduction to Bioinformatics

Monsoon 2017: Developmental Biology & Introduction to Omic Technologies

Winter 2018: Cancer Biology

  1. 2011-2016: Secretary, Stem Cell Society Singapore (SCSS). Chair, Organizing Committee, SCSS Annual Symposium 2015 with the theme Opportunities and Challenges in Stem Cell Based Therapies.

  1. 2010-2016:  Executive Committee member, SCSS.

  1. 2009-Current: Member, Live Education Task Force, International Society for Advancement of Cytometry (ISAC). Responsible for organizing flow cytometry workshops in India, China & ASEAN regions. From April 2015 coordinating all ISAC workshops in South East Asia including Singapore, Malaysia, Indonesia and Thailand.

  1. 2006- Current: Member, International Society for Stem Cell Research (ISSCR). Local organizing committee member ISSCR Regional Forum Singapore, Nov 2014.

  1. 2012- 2014: Regional Treasurer, Asia, International Society for Cellular Therapy.

  1. 2005-2010: Member Board of Studies, Microbiology, University of Mumbai, India. This Board sets the syllabi for undergraduate & post graduate degree programs and appoints thesis examiners in microbiology for the University of Mumbai. Also a member of the syllabus sub-committee set up by the University to revise M.Sc (Part II) syllabus for Microbiology.

 

  • IAF111216. Tanavde (PI) Jan 2016-Dec 2016. Effect of Biomin’s phytogenic feed additives versus antibiotics on chicken. Awarded by Agency for Science Technology & Research (A*STAR), Singapore.
  • IAF 111079.  Tanavde (PI) June 2012- June 2013. Dissecting differences in footprint-free iPSC lines using RNASeq IonPGM Sequencer. Awarded by Agency for Science Technology & Research (A*STAR), Singapore for collaboration with Life Technologies.
  • CRC Life Technologies       Lakshmipathy (PI) June 2012 – June 2013. Dissecting differences in footprint-free iPSC lines using RNASeq IonPGM Sequencer. Awarded by Life Technologies, Carlsbad, USA. External PI
  • CRC Life Technologies       Lakshmipathy (PI) June 2011 – December 2011. Cell based Assays to Bridge Epigenome & Function. Awarded by Life Technologies, Carlsbad, USA. External PI


Contact

1, Division of Biological & Life Sciences,
Ahmedabad University,
Central Campus,
Navrangpura, Ahmedabad,
Gujarat, India

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