Research Interests: Adult Stem Cells, Mirna Regulation Of Cell Differentiation, Cancer Biomarkers, Connecting Transcriptome To Cellular Phenotype.
Mentor: Venture Studio, Ahmedabad University, India.
Director & Scientific Advisory Board Member: iBioAnlaysis Pvt. Ltd. Ahmedabad, India.
Adjunct Principal Investigator: Bioinformatics Institute, Agency for Science Technology & Research (A*STAR), Biopolis, Singapore
Dr. Vivek Tanavde joined Ahmedabad Unviersity in 2017. Prior to this, he was a Principal Investigator at the Bioinformatics Institute, Singapore for more than 10 years. He was also heading the Hematopoietic Stem Cell Lab at Reliance Life Sciences, Mumbai where his work focused on developing mesenchymal stromal cell based therapies for cardiac and neuronal disorders. From 1999 to 2002 he was a post doctoral fellow with Dr. Curt Civin at the Sidney Kimmel Cancer Centre, Johns Hopkins University working on expansion of hematopoietic stem cells from umbilical cord blood. Dr. Tanavde obtained his Ph.D from the Cancer Research Institute, Mumbai (1999) in Applied Biology. He was also the Secretary of the Stem Cell Society, Singapore for 5 years & serves on the education committee of the International Society for Advancement of Cytometry (ISAC).
The focus of my group is to achieve targeted differentiation of Mesenchymal stromal cells (MSC) by regulating signaling pathways. MSC have the potential of differentiating into a variety of different cell types & therefore offer therapeutic potential to treat a variety of disorders. Therefore it is important to understand the precise mechanisms involved in MSC differentiation, how these mechanisms are regulated and how to manipulate these to achieve differentiation into the desired lineage.Previously we have identified signaling pathways critical for bone marrow derived MSC growth and differentiation (Ng Blood 2008) & miRNA networks that regulate signaling pathways in MSC (Koh BMC Genomics 2010). In the past few years my lab has focused on understanding the role of miRNAs in regulating MSC differentiation. Tools & approaches developed by our group for understanding MSC differentiation are also being used by our collaborators to understand embryonic stem cell (ESC) differentiation and the response of embryonic stem cells to toxins in the environment.
We are also interested in connecting the trasncriptome data to cellular phenotype. This is difficult but becoming increasingly important with the advent of Next Generation Sequencing (NGS) technologies. We can now generate accurate records of DNA sequence as well of the transcriptome with sensitivity to the single molecule level However what this data means and how this can help us interpret the cellular phenotype still remains a challenge. We have developed tools & approaches to solve this issue & sucessfuly connected transcriptome data to phenotypes in MSC (Guneta 2016, Takeda 2016), ESC (Wong 2016), skin cells (Sundaram 2013), hair follicles as well as developong zebrafish organs (Vaz 2016).
Winter 2017: Introduction to Bioinformatics
Monsoon 2017: Developmental Biology & Introduction to Omic Technologies
Winter 2018: Cancer Biology