Research Interests: Adult Stem Cells, miRNA Regulation Of Cell Differentiation, Cancer Biomarkers, Connecting Transcriptome To Cellular Phenotype.
Advisory Board Member: Venture Studio, Ahmedabad University, India.
Advisory Board Member: Bhavans Research Centre, Bhavans College, Mumbai, India.
Director & Scientific Advisory Board Member: iBioAnlaysis Pvt. Ltd. Ahmedabad, India.
Adjunct Principal Investigator: Bioinformatics Institute, Agency for Science Technology & Research (A*STAR), Biopolis, Singapore
Member, Live Education Task Force, International Society for Advancement of Cytometry, USA
Dr. Vivek Tanavde joined Ahmedabad Unviersity in 2017. Prior to this, he was a Principal Investigator at the Bioinformatics Institute, Singapore for more than 10 years. He was also heading the Hematopoietic Stem Cell Lab at Reliance Life Sciences, Mumbai where his work focused on developing mesenchymal stromal cell based therapies for cardiac and neuronal disorders. From 1999 to 2002 he was a post doctoral fellow with Dr. Curt Civin at the Sidney Kimmel Cancer Centre, Johns Hopkins University working on expansion of hematopoietic stem cells from umbilical cord blood. Dr. Tanavde obtained his Ph.D from the Cancer Research Institute, Mumbai (1999) in Applied Biology. He was also the Secretary of the Stem Cell Society, Singapore for 5 years & serves on the education committee of the International Society for Advancement of Cytometry (ISAC).
My current focus at Ahmedabad University is to develop saliva based diagnostics for cancer. My group is part of the oral cancer cluster at Ahmedabad University. We are currently assessing the utility of salivary exosomal miRNAs in understanding initiation and progression of oral cancer. We are also assessing the utility of cell free DNA from saliva for cancer diagnosis. Liquid biopsies are becoming increasingly important in cancer diagnosis, given their ease of collection and the fact that they accurately reflect molecular changes happening in tumours, especially hard to reach tumours. Saliva is a useful body fluid for liquid bopsies, but the challenge of isolating good quality RNA from saliva has hindered previous efforts to use saliva for liquid biopsy. We aim to solve this problem by studying RNA from salivary exosomes. Since exosomes encapsulate the RNA it remains protected and isolating exosomes can lead to good quality RNA from saliva. We have identified putative biomarkers for predicting progression and chemoresistance in oral cancer. Apart from assessing their utility as biomarkers, we are also interested in understanding the role these miRNAs play in tumour progression. Previously my laboratory has identified signaling pathways critical for bone marrow derived MSC growth and differentiation (Ng Blood 2008) & miRNA networks that regulate signaling pathways in MSC (Koh BMC Genomics 2010). We are deconvoluting similar miRNA-mRNA networks in oral squamous cell carcinoma. In addition we are also assessing the utility of serum exosomal miRNAs for early detection of glioblastoma.
Relevant Book Chapters
“In-Vitro Culture of MSC and a Process for the Preparation Thereof", Patent granted in South Africa (No ZA200404101), 2005.
Winter 2022: Advanced Cell Biology Lab, Foundation Studio: Water
Monsoon 2021: Cancer Biology
Winter 2021: Advanced Cell Biology Lab, Foundation Studio: Water
Monsoon 2020: Cancer Biology, Developmental Biology