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ZnO nanoparticles induced inflammatory response and genotoxicity in human blood cells: A mechanistic approach

July 02, 2015

The wide application of zinc oxide nanoparticles (ZnO NPs) in cosmetics, paints, biosensors, drug delivery, food packaging and as anticancerous agents has increased the risk of human exposure to these NPs. Earlier in vitro and in vivo studies have demonstrated a cytotoxic and genotoxic potential of ZnO NPs. However, there is paucity of data regarding their immunomodulatory effects. Therefore, the present study was aimed to investigate the immunotoxic potential of ZnO NPs using human monocytic cell line (THP-1) as model to understand the underlying molecular mechanism.

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Keywords

Zinc oxide nanoparticles; Cellular uptake; Cytokines; Oxidative stress; Immunotoxicity