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Ajay Karakoti

Associate Professor
Ph.D (Materials Science), University of Central Florida
Areas of interest
Catalyst, Materials Science, Nanomaterials, Surface Science, Drug Delivery, Synthetic antioxidant , Point of Care Diagnostic Devices

Associate Professor – School of Engineering and Applied Sciences, Division of Biological and Life Science - School of Arts and Science, Ahmedabad University, India

Mentor – Venture Studio, Ahmedabad University, India

Education: Dr. Ajay Karakoti has an interdisciplinary educational background with B.Sc. & M.Sc. in Chemistry (Delhi University) and M.Tech (IIT Bombay) and Ph.D in Materials Science. Ajay received his PhD (2010) from University Central Florida (UCF), Orlando, USA in the area of nanoscale science and technology.

Publications and Projects: Dr. Karakoti has co-authored 60 publications including review articles in international peer reviewed journals and has been granted 3 patents and has applied for 2 patents. Currently he has over 4500 citations and an H-index of 30. He has worked on a variety of industrial and academic projects such as sustained inorganic nanomaterials based anti-cancerous compounds, controlled drug release, targeted drug delivery, thermal conversion of methanol to hydrogen, electrochemical conversion of alcohols to energy, gas and chemical sensors, inorganic antioxidants, hydrophobic coatings, photocatalytic decomposition of organic contaminants, antireflective sol-gel coatings and hybrid solar cells.

Work Experience: Prior to joining Ahmedabad University, Dr. Karakoti worked as a Principal Scientist at Battelle Science and Technology Pvt Ltd from September 2012 to October 2014 where he worked on developing platform nanomaterials based technologies for wide range of applications in automotive, energy, environment and healthcare applications. Dr. Karakoti also worked at the Environmental and Molecular Sciences Laboratory at Pacific Northwest National Laboratory as a Research Associate following his Ph.D where he was a part of various projects in the areas of hybrid solar cells, nanomaterials for drug delivery, assessing the toxicity of nanomaterials and development of nanoparticles based chemical sensors for detection of peroxides.

Current Research: At Ahmeadabad University Dr. Karakoti’s research is focused on development of novel redox active nanomaterials for treatment of diseases caused by reactive oxygen species and development of sensing platform for diagnosis of various communicable and non-communicable diseases. In addition his interests span across materials science and nanomaterials in the areas of development of advanced functional coatings and catalytic materials for applications in engineering industries, water treatment and conversion of waste to value.

Career Highlights

  • 60 publications in peer-reviewed journals, 20+ presentations at international conferences, book chapter, 4500+ citations and an H index of 30
  • Funded by DST (ECRA), DBT (BioNest) and GICT (Infrastructure support)
  • Mentored Start-up “Delta H Solutions” at Venture Studio, Ahmedabad University for creating instant heating and warming solutions (in technical and scale-up aspects);
  • Promoter & Director of Start-up “Parishodhana Technology Pvt Ltd” in India for commercialization of technical R&D products
  • “M.T. Thomas Award” for “Outstanding Postdoctoral Achievements” at Environmental and Molecular Sciences Laboratory, Pacific Northwest National Laboratory for the year 2011 (Awarded in 2012)
  • Presidential Doctoral Fellowship for pursuing graduate research, University of Central Florida (UCF), (2005-2009) and Nominated for “Order of Pegasus” (highest award in UCF for overall excellence in academics and community service) by the College of Engineering and College of Graduate Studies 2009
  • AVS Top Level Student Award (Dorothy M. and Earl S. Hoffman Scholarship) (2008)

  • Nano-biotechnology – Detection of cardiac marker (Troponin I) for detection of myocardial infarction, Etching based control of polarity in nano silica surfaces for drug delivery applications, development of colorimetric glucose detection, development of micro HPLC based assay for HbA1c detection, exploring the antibacterial properties of cerium oxide nanoparticles
  • Ligand-Surface Interaction – Surface functionalization of cerium oxide nanoparticles with carboxylic acids and studying the antioxidant properties modified surfaces, Understanding the effect of environmental conditions on the oxidation state and biological activity of cerium oxide nanoparticles in mitigation of oxidative stress related disorders
  • Microfluidic systems for low cost diagnostics – Development of laser based low cost microfluidic diagnostic devices for HbA1c and glucose detection, direct synthesis of liposomes and drug encapsulated liposomes using microfluidics
  • Applied Nanotechnology – Catalytic nanoparticles for reduction in NOx and COx emission from fire retardant grade polyurethanes, thin film anti-stain and easy clean coatings, gold-ceria core shell NPs for catalytic applications

Externally Funded Programs

  • Early Career Research Award – Science and Engineering Research Board, Department of Science and Technology, India – INR 34 Lakh “Redox Tunable Nanozymes” Sanctioned July 2016 (Role PI)
  • Infrastructure Support Grant – Gujarat Institute of Chemical Technology, Gujarat India – INR 85 Lakh  “Central Research and Instrumentation Facility”, January 2016 (Role PI)
  • Bioncubation Support Program – Biotechnology Industry and Research Assistance Council – Department of Biotechnology, India – INR 5.4 Cr “BioNest – Bioincubator at Ahmedabad University” Sanctioned November 2016 (Role – Participant)

  1. N.V. Srikanth Vallabani, Ajay S. Karakoti, Sanjay Singh, “ATP-mediated intrinsic peroxidase-like activity of Fe3O4-based nanozyme: One step detection of blood glucose at physiological pH”, Colloids and Surfaces B: Biointerfaces, Volume 2017, 153, 52–60
  2. Ragini Singh, A. S. Karakoti, William Self, Sudipta Seal, and Sanjay Singh, “Redox-Sensitive Cerium Oxide Nanoparticles Protect Human Keratinocytes from Oxidative Stress Induced by Glutathione Depletion” Langmuir, Langmuir, 2016, 32 (46), 12202–12211
  3. S. Sanghavi, W. Wang, M.I Nandasiri, A.S. Karakoti, W. Wang, P. Yang, S. Thevuthasan, Investigation of trimethylacetic acid adsorption on stoichiometric and oxygen-deficient CeO2 (111) surfaces, Physical Chemistry Chemical Physics, 2016, 18, 15625 – 15631
  4. Fluorescent magnesium nanocomplex in a protein scaffold for cell nuclei imaging applications, A. Pandya, A. Tripathi, R. Purohit, S. Singh, M.I. Nandasiri, A.S. Karakoti, S.P. Singh and R. Shanker, RSC Advances, 2015, 5 (114), 94236 – 94240
  5. J. Shah, R. Purohit, R. Singh, A. S. Karakoti and S. Singh, ATP-enhanced peroxidase-like activity of gold nanoparticles, Journal of Colloid and Interface Science, 2015, 456, 100 – 107
  6. A.S. Karakoti, R. Shukla, R. Shanker and S. Singh, “Surface Functionalization of Quantum Dots for Biological Applications, Advances in Colloids and Interface Science, 2015, 215, 28 – 45
  7. T. Inerbaev, A.S. Karakoti, S.V.N.T Kuchibhatla, A. Kumar, A.E. Masunov, S. Seal, “Aqueous medium induced optical transitions in cerium oxide nanoparticles” Physical Chemistry Chemical Physics, 2015, 17, 6217-6221
  8. J.M. Dowding, W. Song, K. Bossy, A.S. Karakoti, A. Kumar, A. Kim, B. Bossy, S. Seal, M.H. Ellisman, G. Perkins, W.T. Self, E. Bossy-Wetzel, “Cerium oxide nanoparticles protect against Aβ-induced mitochondrial fragmentation and neuronal cell death” Cell Death and Differentiation, 2014, 21(10),1622 – 32
  9. S. Giri, A.S. Karakoti, R.P. Graham, J.L. Maguire, C.M. Reilly, S. Seal, R. Rattan, V. Shridhar, “Nanoceria: a rare-earth nanoparticle as a novel anti-angiogenic therapeutic agent in ovarian cancer” PloS One 2013, 8 (1), e54578
  10. S. Hirst, A.S. Karakoti, S. Singh, W. Self, R. Tyler, S. Seal and C.M. Reilly, “Bio-distribution and in-vivo antioxidant effects of cerium oxide nanoparticles in mice” Environmental Toxicology, 2013, Volume 28, Issue 2, 107 – 118
  11. Z. Lu, A.S. Karakoti, L. Velarde, W. Wang, P. Yang, S. Thevuthasan, H. Wang, “Dissociative binding of carboxylic acid ligand on nanoceria surface in aqueous solution: A joint in situ spectroscopic characterization and first-principles study, The Journal of Physical Chemistry C, 2013, 117 (46), 24329 – 24338
  12. J. Gaynor, A.S. Karakoti, S. Sanghavi, P. Nachimuthu and S. Thevuthasan “Enzyme-free spectrophotometric detection of hydrogen peroxide from single layer of cerium oxide nanoparticles immobilized on poly(4-vinylpyridine) SAMs” Journal of the Materials Chemistry B, 2013, 1, 3443 – 50
  13. D.R. Baer, M.H. Engelhard, G.E. Johnson, J. Laskin, J. Lai, K. Mueller, P. Munusamy, S. Thevuthasan, H. Wang, N. Washton, A. Elder, B.L. Baisch, A.S. Karakoti, S.V.N.T. Kuchibhatla, D-W. Moon, “Surface characterization of nanomaterials and nanoparticles: Important needs and challenging opportunities”, Journal of Vacuum Science & Technology A, 2013, 31 (5), 050820
  14. A.S. Karakoti, P. Munusamy, K. Hostetler, V. Kodali, S. Kuchibhatla, G. Orr, J.G. Pounds, J.G. Teeguarden, B.D. Thrall, and D.R. Baer, “Preparation and characterization challenges to understanding environmental and biological impacts of nanoparticles” Surface and Interface Analysis, 2012, 44 (8), 882 – 889
  15. A.S. Karakoti, P. Munusamy, B.D. Thrall, J.G. Pounds, J.G. Teeguarden, J.E. Amonette, G. Orr, P.G. Tratnyek, J.T. Nurmi and D.R. Baer, “Testing in EHS: What is the current status of experimentation?” Proceedings of 2011 11th IEEE International Conference on Nanotechnology, 2012, pages 18 – 19, (DOI - 10.1109/NANO.2011.6144671)
  16. V. Turkowski, S. Babu, D. Le, M. K. Haldar, A. Wagh, Z. Hu, A.S. Karakoti, A.J. Gesquiere, B. Law, S. Mallik, T. S. Rahman, M. N. Leuenberger and S. Seal “Linker-induced anomalous emission of organic molecule-conjugated metal oxide nanoparticles”, ACS Nano, 2012, 6 (6), 4854 – 4863
  17. U.M. Bhatta, I.M. Ross, D. Sayle, T.X.T. Sayle, A.S. Karakoti, D. Reid, S. Seal, G. Möbus, “Electron beam induced surface morphology changes of CeO2nanocrystals: An in-situ aberration corrected TEM study”, 2012, 12th IEEE International Conference on Nanotechnology (IEEE-NANO), August 2012, Birmingham UK, pages 1 – 4
  18. S. Kuchibhatla, A.S. Karakoti, S. Thevuthasan, S. Seal, D. R. Baer. 2012 “Influence of aging on the properties of cerium oxide nanoparticles – Implications to quantum confinement effect” Proceedings of 2011 11th IEEE International Conference on Nanotechnology, August 2011 Oregon, United States, 646 – 650
  19. A.S. Karakoti, S. Sanghavi, P. Nachimuthu, S. Thevuthasan, “Probing the size and environment induced phase transformation in CdSe Quantum Dots”  JPC Letters, 2011, 2, 2925 – 2929
  20. A.S. Karakoti, S. Das, S. Thevuthasan and S. Seal, “PEGylated inorganic nanoparticles”, Angewandte Chemie (International Edition), 2011, 50 (9), 1980 – 1994
  21. L. Kong, X. Cai, X. Zhou, L. Wong, A.S. Karakoti, S. Seal and J.F. McGinnis, “Nanoceria extend photoreceptor cell lifespan in tubby mice by modulation of apoptosis/survival signaling pathways, Neurobiology of Disease, 2011, 42 (3), 514 – 523
  22. S. Singh, T. Pirmohammed, A.S Karakoti, A. Kumar, S. Seal and W. Self, “Phosphate dependent shift in redox state of cerium oxide nanoparticles leads to altered catalytic activity”, Biomaterials, 2011, 32 (28), 6745 – 6753
  23. L. Alili, M. Sack, A.S. Karakoti, S. Teuber, K. Puschmann, S. Hirst, C. M. Reilly, K. Zanger, W. Stahl, S. Das, S. Seal, P. Brenneisen, “Combined cytotoxic and anti-invasive properties of redox-active nanoparticles in tumor-stroma interactions”, Biomaterials, 2011, 32 (11), 2918 – 2929
  24. N. Shirato, J. Strader, A. Kumar, A. Vincent, P. Zhang, A.S. Karakoti, P. Nachimuthu, H-J. Cho, S. Seal, R. Kalyanaraman, “Thickness dependent self-limiting 1-D tin oxide nanowire arrays by nanosecond pulsed laser irradiation”, Nanoscale, 2011, 3 (3), 1090 – 1101
  25. J.M. Anderson, J. Patel, A.S. Karakoti, N. Greenletch, D.J. Diaz, S. Seal, “Aging effects of nanoscale ceria in ceria-platinum composite electrodes for direct alcohol electro-oxidation”, Electrochimica Acta, 2011, 56 (5), 2541 – 2546
  26. X-H Zhou, L.L Wong, A.S. Karakoti, S. Seal, J.F. McGinnis, “Nanoceria inhibit the development and promote the regression of pathologic retinal neovascularization in the Vldlr knockout mouse”, PLOS ONE, 2011, 6 (2), e16733
  27. A.S. Karakoti, J.E.S. King, A. Vincent and S. Seal, “Synthesis dependent core level binding energy shift in the oxidation state of platinum coated on ceria-titania and its effect on the decomposition of methanol” Applied Catalysis A-General, 2010, 388 (1-2), 262 – 271
  28. A.S. Karakoti, S. Singh, J. Dowding, S. Seal and W. Self, “Redox active radical scavenging nanomaterials” Chemical Society Reviews, 2010, 39 (11), 4422 – 4432
  29. A.S Karakoti, O. Tsigkou, S. Yue, P.D. Lee, M.M Stevens, J.R. Jones,  S. Seal, “Rare earth oxides as nanoadditives in 3-D nanocomposite scaffolds for bone regeneration”, Journal of Materials Chemistry, 2010, 20 (40), 8912 – 8919
  30. J-H. Zou, J-H. Liu, A.S. Karakoti, A. Kumar, D. Joung, Q-A Li, S.I. Khondaker, S. Seal, L. Zhai, “Ultralight multiwalled carbon nanotube aerogel”, ACS Nano, 2010, 4 (12), 7293 – 7302
  31. V. Singh, A.S. Karakoti, A. Kumar, A. Saha, S. Basu, S. Seal, “Precursor dependent microstructure evolution and nonstoichiometry in nanostructured cerium oxide coatings using the solution precursor plasma spray technique”, Journal of the American Ceramic Society, 2010, 93 (11), 3700 – 3708. 
  32. S. Singh, A. Kumar, A.S. Karakoti, S. Seal, W. Self, “Unveiling the mechanism of uptake and sub-cellular distribution of cerium oxide nanoparticles” Molecular Biosystems, 2010, 6 (10), 1813 – 1820
  33. V. Singh, S. Babu, A.S. Karakoti, A. Agarwal, S. Seal, “Effect of submicron grains on ionic conductivity of nanocrystalline doped ceria”, Journal of Nanoscience and Nanotechnology, 2010, 10 (10), 6495 – 6503
  34. J. Anderson, A.S. Karakoti, D.J. Diaz and S. Seal “Nanoceria modified platinum-gold composite electrodes for electrochemical oxidation of methanol and ethanol in acidic media” Journal of Physical Chemistry C, 2010, 114, 4595 – 4602
  35. R.K. Sharma, A.S. Karakoti, S. Seal, L. Zhai, “ Multiwall carbon nanotubes poly(4-styrenesulfonic acid) supported polypyrrole/manganese oxide nano-composites for high performance electrochemical electrodes”, Journal of Power Sources, 2010, 195, 1256 – 1262
  36. T. Pirmohamed, J. Dowding, B. Wasserman, E. Heckert, A.S. Karakoti,  J.E.S. King, S. Seal and W.T. Self “Nanoceria exhibit redox state dependent catalase mimetic activity” Chemical Communications, 2010, 46, 2736 – 2738
  37. A.S. Karakoti, S. Singh, A. Kumar, M. Malinska, K. Wozniak, W. Self and S. Seal, “PEGlyated nanoceria as radical scavenger with tunable redox chemistry” Journal of the American Chemical Society, 2009 131, 14144 – 145
  38. A. Vincent, T. Inerbaev, S. Babu, A.S. Karakoti, W. T. Self, A.E. Masunov and Sudipta Seal, “Tuning hydrated nanoceria surfaces: Experimental/theoretical investigations of ion exchange and implications in organic inorganic interactions” Langmuir, 2009, 25, 10998 – 11007
  39. S. Hirst, A.S. Karakoti, R. Tyler, N. Sriranganathan, S. Seal and C. Reilly, “Inhibition of inflammatory mediator production by cerium oxide nanoparticles” Small, 2009, 24, 2848 – 2856
  40. B. Schanen, A.S. Karakoti, S Seal, D. Drake, W. Warren and W. Self, “Exposure to titanium dioxide nanomaterials provokes inflammation of an in vitro human immune construct”, ACS Nano, 2009, 3, 2523 – 32
  41. A. Kumar, S. Babu, A.S. Karakoti, A. Schulte and S. Seal, “Luminescence properties of europium doped cerium oxide nanoparticles- role of vacancy and oxidation states”, Langmuir, 2009, 25 (18), 10998 – 1007
  42. S.V.N.T. Kuchibhatla, A.S. Karakoti, D.C. Sayle, H. Heinrich and S. Seal, “Symmetry driven spontaneous self-assembly of nanoscale ceria building blocks to fractal superoctahedral”, Crystal Growth and Design, 9 (3), 2009, 1614 – 20 (Cover Page Article)
  43. N. Bhargava, M. Das, A.S. Karakoti, S. Patil, J.F. Kang, M. Stancescu, M.S. Kindy, S. Seal and J.J. Hickman, “Regenration of adult mice motoneurons utilizing a defined system and anti-oxidant nanoparticles” Journal of Nanoneuroscience, 2009, 1, 130 – 143
  44. A.S. Karakoti, Satyanarayana VNT Kuchibhatla, D.R. Baer, S. Thevuthasan, Dean C. Sayle, S. Seal, “Self-assembly mechanism of nanostructures in ice moulds”, Small, 2008, 4, 1210 – 16
  45. A.S. Karakoti, N.A. Monteiro-Riviere, R. Narayan, W. Self, J. McGinnis and S. Seal, “Nanoceria as antioxidant - synthesis and biomedical applications,” JOM, March 2008, 33 – 37
  46. E. Heckert, A.S. Karakoti, S. Seal, and W.T. Self, “The role of cerium redox state in the catalytic reaction of superoxide with nanoceria”, Biomaterials, 2008, 29, 2705 – 09
  47. D.C. Sayle, S. Seal, Z. Wang, B.C. Mangili, D.W. PriceA.S. Karakoti, S.V.N.T. Kuchibhatla, Q. Hao, G. Mobus,  X. Xu, T.X.T Sayle, “Mapping nanostructure: A systematic enumeration of nanomaterials by assembling nanobuilding blocks at crystallographic positions”, ACS Nano, 2008, 2, 1237 – 51
  48. D.R. Baer, J.E. Amonette, M.H. Engelhard, D.J. GasparA.S. Karakoti, S. Kuchibhatla, P. Nachimuthu, J.T. Nurmi, Y. Qiang, V. Sarathy, S. Seal, A. Sharma, P.G. Tratnyek, C.M. Wang, “Characterization challenges for nanomaterials”, Surface and Interface Analysis, 2008, 40, 529 – 37
  49. K. Balani, T. Zhang, A.S. Karakoti, W.Z. Li, S. Seal, A. Agarwal, “In situ carbon nanotube reinforcements in a plasma-sprayed aluminum oxide nanocomposite coating”, Acta Materialia, 2008, 56, 571 – 579
  50. K.S. Babu, A.S. Karakoti and S. Seal, “A cost effective nanostructure rare earth catalytic coating to prevent environmental degradation” Steel Tech, 2008, 2, 26 – 29
  51. A.S. Karakoti, Satyanarayana VNT Kuchibhatla, K. Suresh Babu, S. Seal, “Direct synthesis of ceria nanoparticles in polyhdroxyl groups using different oxidizing agents”, Journal of Physical Chemistry C, 2007; 111(46); 17232 – 40
  52. D.J. Diaz, N. Greenletch, A. Solanki, A.S. Karakoti, S. Seal, Novel nanoscale ceria–platinum Composite electrodes for direct alcohol electro-oxidation, Catalysis Letters, 2007, 119, 319-326
  53. S.V.N.T. Kuchibhatla, A.S. Karakoti, D. Bera and S. Seal, "One dimensional nanomaterials", Progress in Materials Science, 52, 2007, 699 – 914
  54. A. Vincent , S. Babu, E. Brinley, A.S. Karakoti, S. Deshpande, S. Seal, Role of catalyst on refractive index tunability of porous silica antireflective coatings by sol-gel technique, Journal of Physical Chemistry C, 2007, 111, 8291 – 8298
  55. S. DeshpandeA.S. Karakoti, G. Londe, H.J. Cho,  S. Seal, "Room temperature hydrogen detection using 1-d nanostructured tin oxide sensor” Journal of Nanoscience and Nanotechnology, 2007, 7, 3354-57
  56. S.V.N.T. Kuchibhatla, A.S. Karakoti and S Seal, Hierarchical assembly of inorganic nanostructure building blocks to octahedral superstructures — a true template-free self-assembly, Nanotechnology, 2007, 18, 075303 – 307
  57. S.V.N.T. Kuchibhatla, A.S. Karakoti and S. Seal, Colloidal stability by surface modification, JOM, 2005, 57, 52 – 56
  58. A.S. Karakoti, L.L. Hench, and S. Seal, “The potential toxicity of nanomaterials—the role of surfaces”, JOM, 2006, 58(7), 77 – 81
  59. A.S. Karakoti, R. Filmalter, D. Bera, S.V.N.T. Kuchibhatla, A. Vincent, and S. Seal, “Spiral growth of one dimensional titania nanostructures using anodic oxidation”, Journal of Nanoscience and Nanotechnology, 6, 2006, 2084 – 89
  60. A.S. Karakoti, D.K. Pattanayak, A.S. Khanna, T.R. Rama Mohan, V.P. Soni, Polymer/AW coating on stainless steel, Transactions of PMAI, Vol. 29, December 2003, 06 – 12

  • Analytical Chemistry                          
  • Biophysics and Instrumentation         
  • Introduction to Materials Science & Engineering
  • Microscopy and Imaging       
  • Environmental Science
  • Physical Chemistry   

Member of 

  • American Chemical Society
  • Royal Society of Chemistry
  • Materials Research Society of India
  • Powder Metallurgy Association of India

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Contact

Lab 7, Division of Biological & Life Sciences,
Ahmedabad University,
Central Campus,
Navrangpura, Ahmedabad,
Gujarat, India

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