Research Interests: Bioinformatics, Computational Biophysics, Data Science.
Dr. Manish Datt is an assistant professor at Division of Biological & Life Sciences, Ahmedabad University since April 2015. For the doctoral research, he joined Institute of Microbial Technology, Chandigarh, in 2004 to do research in the field of Bioinformatics. After completing his interdisciplinary education in life science and computational science, he moved to Case Western Reserve University, Cleveland, OH, USA to acquire post-doctoral training from 2010 to 2012. In 2012 he returned to join as a research scientist at the International Centre for Genetic Engineering and Biotechnology, New Delhi. He has been a visiting assistant professor at Olin College of Engineering from Jan-May 2017. Dr. Datt is actively involved in development and implementation of project-based courses at Ahmedabad University.
Dr Datt has broad training in life sciences, bioinformatics, and computational biophysics. He has extensive experience in simulating dynamics of macromolecules and their complexes using all-atom molecular mechanic force-fields. He has strong expertise in protein structure analyses and modeling interaction of proteins with other biomolecules. During postdoctoral research, he assiduously investigated pharmaceutically important proteins using molecular modeling and docking methods. He has successfully completed project on Hidden Markov Model based genome annotation for identification of potential drug targets in fungal pathogens. In addition, he has developed an algorithmic workflow for annotation of disease-associated mutations in human proteins. He has proficiency in scientific programming and high performance computing under different platforms. Dr Datt has authored 20 publications in international journals and also has one US patent.
Dr Datt’s research is focused on the application and development of in silico tools for translational therapeutic research. One of the thrust areas of the lab is to understand structure and dynamics of proteins using structural bioinformatics and computational biophysics methods. Development of tools for annotation of disease-associated mutations in the human genome is also being pursued in his lab.
Courses taught at DBLS:
Basics of Bioinformatics
Computational Structural Biology
Introduction to programming
Course(s) taught at SEAS:
Course(s) taught across AU:
Human Microbiome - Friendly Bacteria
Independent Study Program